The hair growth promoting effect of ascorbic acid 2-phosphate, a long-acting Vitamin C derivative
February 2006
in “Journal of Dermatological Science”
TLDR A long-acting Vitamin C derivative helps hair grow by stimulating cells and increasing growth factors.
In the 2006 study, researchers investigated the effects of ascorbic acid 2-phosphate (Asc 2-P), a stable derivative of Vitamin C, on hair growth. They found that Asc 2-P significantly stimulated the growth of dermal papilla cells and promoted the elongation of hair shafts in isolated hair follicles cultured in vitro. The most effective concentration of Asc 2-P for dermal papilla cell growth was 0.25 mM, but it did not stimulate growth in outer root sheath (ORS) keratinocytes. Additionally, Asc 2-P treatment increased the mRNA level of insulin-like growth factor 1 (IGF-1) by 3.8-fold in dermal papilla cells, suggesting that Asc 2-P may induce the secretion of growth factors that proliferate and differentiate keratinocytes, leading to hair shaft elongation. In an animal model, Asc 2-P at 250 mM induced an earlier transition from the telogen phase to the anagen phase of the hair cycle. These findings suggest that Vitamin C or its derivatives could play a role in regulating mesenchymal-epithelial interactions in the hair follicle, potentially offering a new approach to treating hair growth disorders.
View this study on jdsjournal.com →
Cited in this study
research Molecular Control of Epithelial–Mesenchymal Interactions During Hair Follicle Cycling
research The hair growth promoting effect of Sophora flavescens extract and its molecular regulation
Sophora flavescens extract may help hair grow by affecting growth factors and blocking a hair-related enzyme.
research Simple and rapid method to isolate and culture follicular papillae from human scalp hair follicles
Researchers developed a quick and easy way to get and grow cells from the base of human hair follicles.
research Androgen Induction of Follicular Epithelial Cell Growth Is Mediated via Insulin-like Growth Factor-I from Dermal Papilla Cells
Male hormones promote hair cell growth by using a growth factor from nearby skin cells.
Related
research Dermal sheath cells contribute to postnatal hair follicle growth and cycling
Skin sheath cells help in hair growth and renewal after birth.
research Molecular Control of Epithelial–Mesenchymal Interactions During Hair Follicle Cycling
research An estrogen receptor pathway regulates the telogen-anagen hair follicle transition and influences epidermal cell proliferation.
Estrogen affects hair growth and skin cell multiplication.