The Growth of Human Dermal Papilla Cells and Dermal Sheath Cells in Vitro
February 2001
in “
Chinese Journal of Dermatology
”
Related Research
8 / 8 results
research Hair Follicle Generation by Injections of Adult Human Follicular Epithelial and Dermal Papilla Cells into Nude Mice
Injecting a mix of human skin and hair cells into mice can grow new hair.
research Hair follicle reformation induced by dermal papilla cells from human scalp skin
Dermal papilla cells can help regrow hair follicles.
research Determination of proliferation and collagen synthesis of human dermal hair papilla cells
The study aimed to determine the proliferation and collagen synthesis of human dermal hair papilla cells. It found that cell proliferation had a high phase on the 11th day in basal culture medium and two high phases on the 5th and 11th days in routine culture medium. Collagen synthesis did not differ among dermal hair papilla cells, dermal sheath cells, and fibroblasts, but the collagen amount was higher in fibroblast medium. This suggested different functions for these cells. The study concluded that routine culture medium was effective for cell growth and proliferation, and that dermal hair papilla and sheath cells had a lower collagen secretion ability compared to fibroblasts.
research Study on Hair Follicle Formation Induced by Dermal Papilla Cells
Dermal papilla cells can help form hair follicles and produce hair.
research Growth kinetics of cultured dermal papilla cells and dermal sheath cells from human hair follicles
research Immortalized Rat Whisker Dermal Papilla Cells Cooperate with Mouse Immature Hair Follicle Buds to Activate Type IV Procollagenases in Collagen Matrix Coculture: Correlation with Ability to Promote Hair Follicle Development in Nude Mouse Grafts
research Experimental Approaches for the Reconstitution of Hair in vitro
The study explored the role of dermal papillae in hair growth using in vitro cultures. It was found that outer root sheath cells (ORSCs) grew more actively when cultured with dermal papillae, suggesting the presence of papilla-derived factors that stimulate ORSC growth. Additionally, epithelial cells from the bulb matrix grew towards implanted dermal papillae, indicating that dermal papillae might produce factors that attract these cells. When the dermal papilla remained attached to the hair bulb matrix, hair and follicle elongation continued for over a week. However, detachment or damage to the papilla-matrix junction suppressed hair and follicle growth, highlighting the importance of this attachment for normal development.
research Co‐culture of Human Hair Follicles and Dermal Papillae in a Collagen Matrix
The study investigated the co-culture of human hair follicles and dermal papillae in a collagen matrix. It was found that when hair follicles were cultured alone, outer root sheath cells formed spike-like structures. However, when dermal papillae were present, these spikes grew more rapidly and elongated towards the papillae, suggesting that dermal papilla cells produce factors that enhance and attract follicular epithelial cell growth. In whole excised follicles, normal hair shaft and follicle elongation occurred when the dermal papilla remained attached to the hair bulb matrix. Conversely, when detached, epithelial cells proliferated to form hair follicle-like structures. This model was considered useful for studying the interaction between follicular epithelial cells and dermal papillae, as well as hair and follicle growth in vitro.