The Effect of Alfacalcidiol and Metformin on Metabolic Disturbances in Women with Polycystic Ovary Syndrome
January 2017
in “
Hormone Molecular Biology and Clinical Investigation
”
TLDR Metformin effectively improves metabolic symptoms in women with PCOS, while alfacalcidiol does not have a significant impact.
In the 2017 study involving 39 women with polycystic ovary syndrome (PCOS), the effects of alfacalcidiol, metformin, and their combination on metabolic disturbances were evaluated over 6 months. The study found that metformin alone significantly reduced body weight, BMI, waist circumference, total body fat, and serum glucose levels. The combination of metformin and alfacalcidiol led to a significant reduction in waist circumference but did not significantly affect other metabolic parameters. Alfacalcidiol alone did not result in significant changes, except for a slight, non-significant increase in HDL cholesterol. The study concluded that vitamin D supplementation by itself does not significantly impact metabolic parameters in women with PCOS and that metformin is the most effective treatment for metabolic changes associated with PCOS.