The Clinical Manifestations of Polycystic Ovary Syndrome and the Treatment Options

January 2023 in “ European journal of biology and medical science research ”

Shilpa Karkera, Earlina Agard, Larysa Sankova

TLDR PCOS symptoms can be managed with medication and lifestyle changes.

Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine disorder in women, particularly those aged 21-34, with a global prevalence ranging from 2.2% to 20%. Common symptoms include menstrual irregularities, hirsutism, weight gain, and insulin resistance. Diagnosis relies on three criteria: ovulatory dysfunction, hyperandrogenism, and polycystic ovaries, with the Rotterdam criteria being the most widely used. Treatment varies based on symptoms and includes Clomiphene Citrate, Letrozole, Oral Contraceptive Pills, and second-line therapies like Gonadotropins, Metformin, and Laparoscopic Ovarian Drilling for menstrual irregularities, and Finasteride, Isotretinoin, Spironolactone, and Flutamide for hyperandrogenism. Lifestyle modifications and weight reduction are also recommended.

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A 30-year-old female with PCOS and male pattern baldness is frustrated with her endocrinologist's recommendation of only Spironolactone and minoxidil, feeling that dutasteride, finasteride, and progesterone would be more effective. Other users suggest various online sources for treatments, warn against self-medicating due to potential risks, and recommend seeking a specialized endocrinologist or considering additional treatments like Inositol, Berberine, and dermaneedling.

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OP is experiencing significant hair loss despite GFC and PRP treatments and has abnormal lab results. They are advised to consult a hair-focused dermatologist for further evaluation.

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High sugar diets may worsen hair loss by increasing 5α-reductase activity and androgen levels, especially in women with PCOS. A low sugar diet might reduce scalp DHT levels, similar to finasteride, but genetics also significantly influence hair loss.

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Related Research

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research High-Dose Spironolactone for Acne in Patients with Polycystic Ovarian Syndrome: A Single-Institution Retrospective Study

3 citations , August 2019 in “Journal of The American Academy of Dermatology”

Higher doses of spironolactone may improve acne in PCOS patients, but side effects are a concern.