The Antiepileptic and Antidepressant-Like Effects of Dexpanthenol in Female Swiss Albino Mice

    February 2022 in “ Clinical and Experimental Health Sciences ”
    Salim Yalçın İnan, Yağmur AÇIKGÖZ
    TLDR Dexpanthenol may help treat epilepsy and depression.
    The study investigated the effects of dexpanthenol on epilepsy and depression in female Swiss albino mice. Dexpanthenol, commonly used as a topical medication, was tested for its potential antiepileptic and antidepressant-like effects. Mice were injected with dexpanthenol or saline, and their responses to induced convulsions and immobility in a forced swim test were observed. The results indicated that dexpanthenol at a dose of 500 mg/kg exhibited significant antiepileptic and antidepressant-like effects without impacting motor coordination. This suggested that dexpanthenol, a low-cost and widely used drug, could have potential therapeutic benefits for epilepsy and depression.
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