Testosterone's Regulation of the HPA Axis Differs for Adolescent and Adult Male Rats

August 2018 in “ Brock University Digital Repository (Brock University) ”

Mostafa Zeidan

testosterone HPA axis corticosterone CORT dihydrotestosterone DHT estradiol vasopressin corticotrophin releasing hormone aromatase parvocellular paraventricular nucleus

TLDR Adolescent male rats release more stress hormones than adults, and testosterone affects them differently.

The study investigated how testosterone regulates the HPA axis differently in adolescent and adult male rats, focusing on stress hormone corticosterone (CORT) release. It was found that adolescent male rats (postnatal day [P] 45) exhibited a heightened CORT response to stress compared to adults (postnatal day [P] 75), potentially due to greater conversion of testosterone to estradiol. Experiments showed that testosterone and dihydrotestosterone (DHT) treatments resulted in lower vasopressin and corticotrophin releasing hormone levels, with no significant differences in CORT levels but consistent patterns with previous findings. The use of aromatase and 5a-reductase inhibitors further supported the hypothesis that the increased stress response in adolescents might be linked to testosterone's conversion to estradiol.

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Testosterone's Regulation of the HPA Axis Differs for Adolescent and Adult Male Rats

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