The Combination of Stromal Vascular Fraction Cells and Platelet-Rich Plasma Mediates the Inflammatory Process in Deep Dermal Burn Injury
December 2023
in “
PubMed
”
New to Platelet-Rich Plasma? There is a guide in the encyclopedia. Read the guide → Studysummary This study on rats found that combining platelet-rich plasma with stromal vascular fraction cells helped accelerate burn wound healing by affecting inflammatory cell counts and COX-2 expression, with differing impacts observed between acute and sub-acute phases of healing. Our plain-language summary of this paper — not a Tressless recommendation.
This study investigated the effects of combining platelet-rich plasma (PRP) and stromal vascular fraction cells (SVFs) on the inflammatory process in deep dermal burn injuries using 30 Wistar rats. The results showed that the local injection of PRP and SVF significantly increased polymorphonuclear (PMN) cells, lymphocyte counts, and COX-2 expression at 8 hours post-injury, indicating an acute inflammatory response. However, in the sub-acute phase, this combination treatment reduced PMN cells and lymphocyte counts more effectively than vaseline, although it did not significantly affect COX-2 expression. Overall, the PRP and SVF combination was effective in accelerating burn wound healing by modulating the inflammatory response.
