Serum Level of Survivin in Patients with Alopecia Areata and Its Association with Disease Severity and Progression

    February 2023 in “ Suez Canal University Medical Journal ”
    Hesham Nada, Samah Gad EL- Hak, Nashwa Hassan, Radwa El‐Sayed Mahmoud Marie
    TLDR Lower survivin levels in blood are linked to more severe and progressing alopecia areata.
    This study investigated the serum level of survivin in 38 patients with alopecia areata (AA) compared to 38 healthy controls. Results showed that AA patients had significantly lower serum survivin levels than controls (p=0.009), with even lower levels in those with progressive disease compared to stable disease (p<0.001). A significant negative correlation was found between survivin levels and both AA severity (p<0.001) and duration (p=0.003). The findings suggest that survivin may play a role in the immune pathogenesis of AA and that its serum level could serve as a predictor for the severity and progression of the disease.
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