Is the Sulfonamide Group of Tamsulosin the Main Factor in the Pathophysiology of Floppy Iris Syndrome?

    January 2018 in “ Haydarpaşa Numune Hastanesi tıp dergisi ”
    Ahmet Ürkmez
    TLDR Tamsulosin's sulfonamide group may contribute to floppy iris syndrome.
    The 2018 study investigated the pathophysiology of Intraoperative Floppy Iris Syndrome (IFIS), a condition first described in 2005 in patients using alpha-blockers. The drug tamsulosin, a selective alpha-adrenergic receptor antagonist commonly prescribed for benign hyperplasia of the prostate, was found to have the strongest association with IFIS. Other drugs that could lead to IFIS included alfuzosin, doxazosin, terazosin, finasteride, labetalol, mianserin, chlorpromazine, donepezil, and other antipsychotic agents. The researchers analyzed the chemical composition of these drugs and hypothesized that the sulfonamide group in tamsulosin might be a causative factor in IFIS. However, the pathophysiological evaluation of IFIS did not yield clear-cut results.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 18 results

      community 7 years finasteride + 2 year dutasteride - Experience

      in Progress Pictures  15 upvotes 8 months ago
      A 35-year-old started finasteride in 2014 for hair loss and maintained hair density for 7 years, occasionally using ketoconazole shampoo. Switched to dutasteride in 2022 due to increased hair fall, experimented with dosages, and found a combination with tamsulosin effective despite initial adverse reactions.

      community 3.5 years progress. Oral Fin + Topical Min

      in Progress Pictures  20 upvotes 1 year ago
      The user shared a 3.5-year hair loss treatment journey, starting with daily finasteride and oral minoxidil, then switching to finasteride 4 times a week and daily topical minoxidil. After about 2 years and 9 months, they added Dutasteride and Tamsulosin Hydrochloride to their regimen, but reduced the frequency due to side effects, and are currently satisfied with the results.

      community My dad 61y/o healed from full bald to full head of hair

      in Finasteride/Dutasteride  175 upvotes 10 months ago
      A user's 61-year-old father regained a full head of hair after four years on dutasteride for his prostate and five months of weight loss and exercise. The user decided to switch from finasteride to dutasteride and continue exercising, inspired by his father's results.

      community Why is everyone not directly advised Dutasteride?

      in Finasteride/Dutasteride  165 upvotes 1 month ago
      Dutasteride is less commonly prescribed for hair loss because it is not FDA-approved for this purpose, unlike finasteride, which is more accessible and preferred due to fewer side effects. Dutasteride may be more effective in reducing DHT but has a longer half-life and potentially more significant side effects.

      community 5ARI (dutasteride) Associated with Adverse Metabolic Effects

       23 upvotes 6 years ago
      Dutasteride is associated with increased blood glucose, HbA1c, LDL cholesterol, and liver enzyme activity, potentially leading to diabetes, NAFLD, and liver metabolism changes. The conversation highlights concerns about these adverse effects and calls for more studies, including on finasteride.

    Related Research

    1 / 1 results