Mesenchymal Stem Cell-Derived Exosomes Can Effectively Improve Hair Count and Terminal Hair Diameter in Androgenetic Alopecia

June 2025 in “ Research Square (Research Square) ”

Xuesong Wang, Jing Pang, Xiuhuan Wang, Xinzhou Liu, Zhenbo Hu, Guoyan Liu

mesenchymal stem cell-derived exosomes androgenetic alopecia intradermal injections hair density hair diameter stem cell exosome injections AGA stem cell exosomes

A study involving 8 male subjects with androgenetic alopecia (AGA) evaluated the safety and efficacy of intradermal injections of stem cell-derived exosomes over 24 weeks. The treatment, administered every 4 weeks, significantly improved hair density and diameter without serious adverse events. These findings suggest that stem cell exosome injections are a promising and safe treatment for promoting hair growth and thickening in male AGA patients, warranting further large-scale research to confirm long-term effects and mechanisms.

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community Anyone Try Microneedling with Exosomes/AAPE?

in Microneedling 2 upvotes 3 years ago

User asks where to purchase exosomes/AAPE for microneedling hair loss treatment. Links to research on hair regeneration therapy, stem cell therapy, exosome therapy, and dermal exosomes provided.

community Microneedling and aloe vera to recruit stem cells.

in Chat 11 upvotes 1 year ago

Microneedling combined with aloe vera may stimulate dormant stem cells in hair loss areas. Minoxidil is also suggested for better results.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 43 upvotes 5 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 447 upvotes 4 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 8 months ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 10 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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