Stability studies of antiandrogenic compounds in Curcuma aeruginosa Roxb. extract

The study analyzed the stability of antiandrogenic compounds, particularly germacrone, in Curcuma aeruginosa Roxb. extract, which is known for its potential in treating hair loss. The research found that germacrone is highly sensitive to temperature, degrading completely at 45°C within 3 days, but remains stable in solution with PEG-40 even after 90 days at the same temperature. The compound's stability was not affected by pH levels between 2.0 and 9.0, and it only slightly degraded in the presence of light when in dried extract form. The study suggests that to maintain the efficacy of the extract, it should be stored as a solution or in solid form at low temperatures. Other sesquiterpenes in the extract showed greater stability than germacrone, and the degradation products of germacrone may have antiandrogenic properties worth investigating.