The Effect of St John's Wort Treatment on Finasteride Metabolism and Identification of New Finasteride Metabolites in Humans

The study investigated the impact of St John’s Wort on the metabolism of finasteride and identified new metabolites of finasteride in humans. It was found that St John’s Wort, a common herbal supplement, could alter the metabolism of finasteride, a medication used to treat conditions like benign prostatic hyperplasia and androgenetic alopecia. The research highlighted the potential for St John’s Wort to affect the efficacy of finasteride by changing its metabolic pathway, which could lead to variations in drug effectiveness and safety. Additionally, the study identified new metabolites of finasteride, contributing to a better understanding of its metabolic profile in humans.