The Effect of St John's Wort Treatment on Finasteride Metabolism and Identification of New Finasteride Metabolites in Humans

This study reviewed the current analytical techniques for estimating finasteride, a drug used for treating benign prostatic hyperplasia, acute urine retention, and male pattern hair loss.

St. John’s wort changes how finasteride works in the body, possibly affecting its effectiveness.

In this study, researchers found that among healthy Korean males, the clearance of finasteride was about 34% lower in individuals with the CYP3A5*3 homozygous allele compared to other genotypes, suggesting dosage adjustments may be necessary considering CYP3A5 and ALT levels to avoid adverse effects.

This study reviews the etiology and treatment of skin cancer, focusing on nanotechnology's role in addressing drug resistance and evaluating nanoparticles' potential to improve treatment outcomes, including overcoming multidrug resistance.

This study describes an analytical technique combining field-enhanced sample stacking with dispersive liquid-liquid microextraction, offering improved sensitivity for detecting finasteride and its metabolite in urine samples from patients treated for androgenetic alopecia.