FASCE: The Benefit of Spironolactone for Treating Acne in Adult Females - Study Protocol for a Randomized Double-Blind Trial

    May 2020
    Alexandra Poinas, Marie Lemoigne, S. Le Naour, Jean‐Michel Nguyen, Solène Schirr-Bonnans, Valéry-Pierre Riche, Florence Vrignaud, L. Machet, Jean-Paul Claudel, M.‐T. Leccia, E. Hainaut, N. Bénéton, Cécile Dert, Aurélie Boisrobert, Laurent Flet, Anne Chiffoleau, Stéphane Corvec, Amir Khammari, Brigitte Dréno
    TLDR Spironolactone is a promising alternative to antibiotics for treating acne in adult females.
    The study aimed to evaluate the efficacy of spironolactone as an alternative treatment for acne in adult females, compared to the commonly used antibiotic doxycycline. Spironolactone was considered a promising option due to its ability to block 5-alpha-reductase receptors and inhibit LH production without causing bacterial resistance or teratogenic risks associated with isotretinoin. The trial involved 200 female participants with acne vulgaris, who were randomized to receive either spironolactone or doxycycline for three months, followed by a placebo. The study was designed to be double-blind for the first six months and open for the last six months. The research was significant in the context of rising antibiotic resistance, offering a potential alternative treatment for adult female acne.
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results

    Related Community Posts Join

    6 / 484 results

      community Spironolactone and pregnancy planning

      in Female  2 upvotes 6 months ago
      A user with AGA uses topical spironolactone 2% due to side effects from the oral form and is concerned about its use during conception and breastfeeding. They seek alternatives to prevent AGA relapse while planning pregnancy and after childbirth.

      community spironolactone pills to topical

      in Research/Science  6 upvotes 6 months ago
      Crushing spironolactone pills and combining them with minoxidil for topical application may be effective for hair loss, with the addition of finasteride suggested. Adding rosemary and peppermint oils can help mask the unpleasant smell.

      community Does the effect of spironolactone on androgenetic alopecia really weaken over time?

      in Female  4 upvotes 9 months ago
      Spironolactone can remain effective for a long time in treating androgenetic alopecia, but it may not completely stop hair loss. Hair loss treatments like spironolactone, finasteride, and dutasteride slow down hair loss rather than cure it, and their effectiveness can vary based on individual response and the aggressiveness of the condition.

      community Spironolactone VS dutasteride for female pattern hair loss

      in Treatment  7 upvotes 1 year ago
      Spironolactone is more potent and lowers testosterone and DHT, while dutasteride only impacts DHT. For female hair loss, checking hormones and considering treatments like oral minoxidil, spironolactone, or topical minoxidil is recommended.

    Related Research

    2 / 2 results