Single-Cell RNA Sequencing Redefines Macrophage Heterogeneity and Function in Wound Healing

November 2025 in “ Wound Repair and Regeneration ”

Mengya Zhao, Zhuo Zuo, Ya Xing Wang, Yanwei Fang, Yulong Sun

single-cell RNA sequencing macrophage heterogeneity wound healing macrophages tissue homeostasis CD301b+ macrophages monocyte-derived macrophages tissue-resident macrophages marker genes SCS

TLDR Single-cell sequencing shows that different types of macrophages have unique roles in wound healing.

This review highlights the transformative role of single-cell sequencing (SCS) in understanding the complexity of skin wound healing, particularly focusing on macrophage heterogeneity and function. SCS reveals that macrophages, crucial for tissue homeostasis, exhibit significant heterogeneity and functional diversity during wound healing. They differentiate into various subtypes, such as CD301b<sup>+</sup> macrophages, monocyte-derived macrophages, and tissue-resident macrophages, each playing distinct roles in the healing process. The review also identifies key marker genes from SCS studies, enhancing our understanding of macrophage roles at the single-cell level in wound healing.

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

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community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

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community My Theory Of Androgenic Alopecia

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community CRISPR Is Curing People Right Now. Genetic Hair Loss is Next?

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