Should Finasteride Be Routinely Given Preoperatively for TURP?

    July 2013 in “ ISRN Urology (Print) ”
    Omar Aboumarzouk, Muhammad Aslam, A W Wedderburn, Kimberly L. Turner, Owen Hughes, Howard Kynaston
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    TLDR Finasteride may reduce bleeding after TURP, but more research needed.
    This document reviews the use of finasteride as a preoperative treatment for transurethral resection of the prostate (TURP). Four randomized controlled trials were analyzed, and the evidence suggests that finasteride can reduce intra- or postoperative bleeding after TURP without any long-lasting complications. Finasteride reduces the amount of dihydrotestosterone (DHT) in the bloodstream, which reduces prostatic size and microvessel density (MVD), ultimately reducing prostatic bleeding/haematuria. However, the disparity between the studies included in the review makes it difficult to make a decisive recommendation based on the results given. Further studies are required to strengthen future recommendations regarding its use as a standard pre-TURP treatment.
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