Change In Sexual Function In Men With LUTS/BPH Associated With Long-Term Treatment With Doxazosin, Finasteride, And Combined Therapy

The study assessed the impact of long-term treatment with doxazosin, finasteride, and combined therapy on sexual function in men with lower urinary tract symptoms (LUTS) using data from the MTOPS trial, which included 2,783 men. Results indicated that men taking 5-alpha-reductase inhibitors (5ARIs) experienced significant declines in ejaculatory function, while those on combined therapy also saw declines in erectile function and sexual problem assessment. In contrast, doxazosin alone did not significantly affect sexual function compared to placebo. The study highlighted the importance of discussing potential long-term negative effects of LUTS drug treatments on sexual function with patients.