Sexual dimorphism of growth plate prehypertrophic and hypertrophic chondrocytes in response to testosterone requires metabolism to dihydrotestosterone (DHT) by steroid 5‐alpha reductase type 1

February 2005 in “ Journal of Cellular Biochemistry ”

Perry Raz, E. Nasatzky, Barbara D. Boyan, Asher Ornoy, Z. Schwartz

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Research cited in this study

6 / 6 results

research Selective Non-Steroidal Inhibitors of 5α-Reductase Type 1

49 citations , January 2004 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.

research 5 Alpha-Reductase Inhibitors: What's New?

47 citations , January 2003 in “Current opinion in urology”

A new drug, dutasteride, is at least as effective as the older drug, finasteride, for treating enlarged prostate and may have additional uses.

research Human Osteoblast-Like Cells Express Predominantly Steroid 5α-Reductase Type 1

56 citations , December 2002 in “The Journal of Clinical Endocrinology & Metabolism”

research The 5α-Recluctase System and Its Inhibitors

124 citations , January 1996 in “Dermatology”

5 alpha-reductase inhibitors, like finasteride, are used to treat conditions like prostate issues and skin disorders.

research Finasteride

86 citations , July 1993 in “Drugs”

Finasteride treats enlarged prostate, shrinks it, improves urination, but may cause sexual dysfunction and isn't for women or children.

research Regulation of Androgen Receptor and 5α-Reductase in the Skin of Normal and Hirsute Women

35 citations , May 1986 in “Clinics in endocrinology and metabolism”

The exact cause of increased 5α-reductase activity leading to hirsutism in women is still unknown.

Related Research

4 / 4 results

research Evaluation of the Therapeutic Effects of AGA Drugs by Measuring Finasteride, Dutasteride, and Dihydrotestosterone in Hair

June 2023 in “Clinica Chimica Acta”

Finasteride and dutasteride effectively reduce DHT in hair, which may help evaluate their treatment success for hair loss.

research The Effects of Finasteride on Scalp Skin and Serum Androgen Levels in Men with Androgenetic Alopecia

65 citations , October 1999 in “Journal of The American Academy of Dermatology”

Finasteride effectively reduces hair loss by decreasing androgen levels.

The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients with Male Pattern Baldness

research The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients with Male Pattern Baldness

59 citations , September 1994 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride reduces scalp DHT levels, potentially treating male pattern baldness.

Comparison of Finasteride, a 5α Reductase Inhibitor, and Various Commercial Plant Extracts in In Vitro and In Vivo 5α Reductase Inhibition

research Comparison of Finasteride, a 5α Reductase Inhibitor, and Various Commercial Plant Extracts in In Vitro and In Vivo 5α Reductase Inhibition

124 citations , January 1993 in “The Prostate”

Finasteride effectively inhibits 5α reductase, while plant extracts like Permixon and Bazoton don't show significant results.