TLDR Severe COVID-19 may increase lung cancer risk and affect treatment in women due to hormonal changes.
This study analyzed sex hormone and cortisol levels in lung tissues of 60 patients with stage I–IIIA non-small cell lung cancer (NSCLC) who had previously contracted COVID-19. Patients were divided into two groups based on COVID-19 severity: 30 with severe or moderate cases and 30 with mild or asymptomatic cases. Results showed that severe COVID-19 altered the hormonal profile in lung tissues, particularly in women, with significant increases in estradiol, cortisol, and progesterone, and a decrease in testosterone. These hormonal changes suggest a potential increase in lung cancer incidence, especially in females, and may affect the disease's progression, response to treatment, and complication rates.
16 citations
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December 2021 in “Frontiers in Endocrinology” Sex hormones may affect COVID-19 severity, with estrogen possibly reducing risk and testosterone potentially increasing it.
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