Sex hormone supplementation improves breathing and restores respiratory neuroplasticity following C2 hemisection in rats

May 2024 in “ Frontiers in Physiology ”

Rebecca Barok, Jessica Grittner, Shawn Miller, Brendan J. Dougherty

sex hormone supplementation 17β-estradiol dihydrotestosterone DHT testosterone phrenic long-term facilitation pLTF neuroplasticity estradiol

TLDR Sex hormone supplements help improve breathing and nerve recovery after spinal injury in rats.

This study investigates the effects of sex hormone supplementation on respiratory function and neuroplasticity in male rats following C2 hemisection spinal cord injury (SCI). SCI often leads to reduced testosterone levels, impairing respiratory neuroplasticity, specifically phrenic long-term facilitation (pLTF). The study involved supplementing rats with either 17β-estradiol (E2) or dihydrotestosterone (DHT) for 7 days, starting one week post-injury. Results showed that while E2 improved overall breathing recovery, both E2 and DHT successfully restored AIH-induced pLTF two weeks after SCI. This suggests that both hormones can aid in respiratory recovery post-SCI, with potential implications for treatment strategies in humans.

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