Setipiprant for Androgenetic Alopecia in Males: Results from a Randomized, Double-Blind, Placebo-Controlled Phase 2a Trial

October 2021 in “ Clinical, Cosmetic and Investigational Dermatology ”

Janet DuBois, Suzanne Bruce, Daniel Stewart, Steven Kempers, Christy Harutunian, Terry Boodhoo, Amy Weitzenfeld, Joan-En Chang-Lin

setipiprant CRTH2 antagonist androgenetic alopecia finasteride placebo AGA Propecia

TLDR Setipiprant did not significantly improve hair growth in men with hair loss.

The study evaluated the efficacy and safety of setipiprant, a CRTH2 antagonist, for treating androgenetic alopecia (AGA) in 169 men over 24 weeks. Results showed no significant improvement in hair growth with setipiprant compared to placebo, although it was well tolerated. Finasteride, used as an unblinded reference, showed greater numerical improvements in hair count but was not formally compared. The study concluded that setipiprant did not significantly enhance hair growth in men with AGA.

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Research cited in this study

17 / 17 results

research Safety Concerns When Using Novel Medications to Treat Alopecia

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research The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride

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research Psychological Effect, Pathophysiology, and Management of Androgenetic Alopecia in Men

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research A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men

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46 citations , October 1999 in “Journal of The American Academy of Dermatology”

Finasteride effectively treats male pattern hair loss with a 1 mg daily dose.

research Finasteride, a Type 2 5α-Reductase Inhibitor, in the Treatment of Men with Androgenetic Alopecia

32 citations , April 1999 in “Expert Opinion on Investigational Drugs”

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research The Psychological Effects of Androgenetic Alopecia in Men

192 citations , June 1992 in “Journal of The American Academy of Dermatology”

Hair loss can cause low self-esteem, anxiety, and depression in men.

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Setipiprant for Androgenetic Alopecia in Males: Results from a Randomized, Double-Blind, Placebo-Controlled Phase 2a Trial

Research cited in this study

research Safety Concerns When Using Novel Medications to Treat Alopecia

research Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men – Short Version

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research Male Androgenetic Alopecia

research The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride

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