SERUM-CONCENTRATIONS OF DEHYDROEPYAN- DROSTERONE-SULFATE IN MEN WITH ANDROGE- NETIC ALOPECIA

The document discussed androgenetic alopecia (AGA), the most common form of hair loss in men and women, characterized by a pattern of hair loss in genetically predisposed individuals. It was identified as a dihydrotestosterone (DHT)-dependent process involving the miniaturization of hair follicles. Although the genetic factors were unknown, the hormonal effects on hair growth were better understood, with local androgen metabolism playing a crucial role. The dermal papilla was highlighted for its role in regulating hair follicle growth through steroidogenic isoenzymes, which could explain differences in androgen sensitivity. These enzymes were considered potential targets for treating AGA or hirsutism.

The document discussed androgenetic alopecia (AGA), the most common form of hair loss in genetically predisposed men and women, characterized by a specific pattern. While the exact genes involved were unknown, the hormonal effects on hair growth were better understood. Human hair follicles were identified as targets for androgens and exhibited active androgen metabolism, capable of converting several androgens through various steroidogenic enzymes. The dermal papilla of hair follicles showed significant activity of type 2 5a-reductase, 3b-HSD, and steroid sulfatase. The document reviewed current knowledge on androgen metabolism in hair follicles and its potential implications for future therapeutic strategies.

The document discussed the role of steroidogenic enzymes in the skin, particularly focusing on the conversion of testosterone to dihydrotestosterone (DHT) by 5a-reductase enzymes, which is linked to androgenetic alopecia. DHT binds more strongly to androgen receptors than testosterone, contributing to hair loss. The study highlighted the development of finasteride, a 5a-reductase inhibitor, which was effective in promoting hair growth by reducing DHT levels in the scalp and plasma. Additionally, it noted that other enzymes could also contribute to DHT production in the scalp, potentially accelerating hair loss in genetically predisposed individuals.

Androgenetic alopecia (AGA) was identified as the most common form of hair loss in both men and women, characterized by a specific pattern in genetically predisposed individuals. The genetic basis was not fully understood, but evidence suggested a polygenic rather than a simple Mendelian trait. AGA was defined as a dihydrotestosterone (DHT)-dependent process, involving the miniaturization of hair follicles. The molecular mechanisms distinguishing androgen-dependent beard growth from hair loss in AGA were unclear. However, advances in research highlighted the role of steroidogenic isoenzymes, particularly type 2 5α-reductase in the dermal papilla, which facilitated the conversion of testosterone to DHT, playing a central role in the pathogenesis of AGA.