Enzymology of the hair follicle.

August 2001 in “ PubMed ”

Rolf Hoffmann

TLDR Hair follicles convert androgens, affecting hair loss patterns.

The document discussed androgenetic alopecia (AGA), the most common form of hair loss in genetically predisposed men and women, characterized by a specific pattern. While the exact genes involved were unknown, the hormonal effects on hair growth were better understood. Human hair follicles were identified as targets for androgens and exhibited active androgen metabolism, capable of converting several androgens through various steroidogenic enzymes. The dermal papilla of hair follicles showed significant activity of type 2 5a-reductase, 3b-HSD, and steroid sulfatase. The document reviewed current knowledge on androgen metabolism in hair follicles and its potential implications for future therapeutic strategies.

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