Importance of Sequential Follow-Up of Autoantibodies in ANA-Positive Patients with Diffuse Hair Loss

The document highlights the importance of sequential follow-up of autoantibodies in ANA-positive patients with diffuse hair loss for early detection of systemic lupus erythematosus (SLE). A case study of a 20-year-old female with diffuse hair loss and high ANA titers illustrates this approach. Despite initial treatment with topical minoxidil and alfatradiol, her condition progressed, revealing positive anti-dsDNA IgG and anti-Sm antibodies, leading to a diagnosis of SLE with lupus nephritis. Treatment with mycophenolate mofetil, hydroxychloroquine, and prednisolone improved her symptoms. The study emphasizes that regular monitoring of autoantibodies can facilitate early intervention and improve patient outcomes by reducing disease progression risks.