Sequence analyses of Type I and Type II chains in human hair and epithelial keratin intermediate filaments: Promiscuous obligate heterodimers, Type II template for molecule formation and a rationale for heterodimer formation

    December 2006 in “ Journal of Structural Biology ”
    Thomasin A. Smith, David Parry
    TLDR Type I and Type II keratin chains can form heterodimers despite sequence differences.
    The study analyzed the sequence differences and similarities between Type I and Type II keratin intermediate filament (IF) chains in human hair and epithelial cells. It found that despite sequence differences, heterodimer formation between hair and epithelial keratin chains is possible, indicating that these differences do not prevent heterodimerization. The research used a comprehensive dataset from the human genome project, ensuring an unbiased analysis. This work provided insights into the structural and functional roles of Type I and Type II chains and offered a rationale for the preference of heterodimer over homodimer formation in keratin IF molecules.
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