Nutritional Roles of Selenium in Cellular and Mouse Aging

    January 2013 in “ University Libraries (University of Maryland) ”
    Tsung-Yu Wu
    TLDR Selenium helps protect cells from aging and damage, especially under stress.
    The study explored the role of selenium (Se) and selenoprotein H (SelH) in cellular aging and genome maintenance, particularly under oxidative stress. SelH was found to protect against cellular senescence through pathways involving ATM and p53. In experiments with MRC-5 human fibroblasts and HeLa cells, SelH knockdown led to increased sensitivity to oxidative stress, which could be mitigated by ATM inhibitors or glutathione analogues. Additionally, mice with Se deficiency exhibited aging phenotypes such as alopecia and bone abnormalities, suggesting Se's role in aging. The study proposed that Se deficiency in mice with short telomeres could model human aging, revealing Se's potential in delaying health span deterioration. The research also identified microRNAs as potential biomarkers for aging and Se deficiency.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 166 results

      community The real stack, the only things you really need.

      in Treatment  1 upvotes 11 months ago
      The conversation discusses a hair loss prevention regimen using a custom topical treatment with Dutasteride, Minoxidil, Latanoprost, Cetirizine, Tretinoin, Vitamin D3, and caffeine, along with supplements like iron, selenium, vitamin D, and vitamin B. The user advises against expensive treatments like LLLT caps and unnecessary natural supplements.

      community Nutritional factors to check for apart from DHT ?

      in Chat  11 upvotes 3 years ago
      The conversation is about identifying nutritional factors that should be checked and supplemented to address diffuse hair loss, including Vitamin D, Biotin, Vitamin C, Vitamin B, Iron, Zinc, Protein, and Omega-3. No specific treatments were mentioned.

      community DHT Blocker without Selenium and Zinc??

      in Female  6 upvotes 1 year ago
      A female user is seeking a DHT blocker without Selenium or Zinc due to hair breakage and is currently using Saw Palmetto, Nature's Bounty Hair, Skin and Nails, Pumpkin seed oil, Dermastamp, and Pura D'or products. She has tried Minoxidil without success and is considering Finasteride but prefers natural options first.

    Similar Research

    5 / 1000+ results