Association Between Scalp Microbiota Imbalance, Disease Severity, and Systemic Inflammatory Markers in Alopecia Areata

October 2024 in “ Dermatology and Therapy ”

Pedro Jesús Gómez‐Arias, Jesús Gay-Mimbrera, Irene Rivera‐Ruiz, Macarena Aguilar-Luque, M. Juan-Cencerrado, Carmen Mochón‐Jiménez, Francisco Gómez‐García, Silvia Sánchez-González, Adriana Ortega‐Hernández, Dulcenombre Gómez‐Garré, Esmeralda Parra-Peralbo, Beatriz Isla-Tejera, Juan Ruano

scalp microbiota alopecia areata inflammation systemic inflammatory markers

Studysummary In this study, researchers observed that alterations in scalp microbiota might be linked to inflammation associated with alopecia areata, but it's unclear if these microbiota changes cause or result from hair loss, necessitating further investigation into their causal relationship and mechanisms.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study explores the potential link between scalp microbiota imbalance and inflammation in Alopecia Areata (AA). While the findings indicate that changes in scalp microbiota may be associated with AA-related inflammation, it remains uncertain if these shifts are a cause or a result of hair loss. The study emphasizes the need for further research to understand the causal relationship and underlying mechanisms.

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Research cited in this study

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research Treatments for Alopecia Areata: A Network Meta-Analysis

October 2023 in “The Cochrane library”

This review identified that baricitinib increases both short- and long-term hair regrowth in patients with alopecia areata compared to placebo, but found inconclusive results for serious adverse effects, while evidence for other treatments remains very uncertain.

research Clinical and Genetic Aspects of Alopecia Areata: A Cutting Edge Review

1 citations , June 2023 in “Genes”

This study highlights the genetic complexities in alopecia areata, emphasizing the role of microRNAs and their association with other immune-related diseases, which could inform targeted treatment strategies.

Incidence Rates of Infections, Malignancies, Thromboembolism, and Cardiovascular Events in an Alopecia Areata Cohort from a US Claims Database

research Incidence Rates of Infections, Malignancies, Thromboembolism, and Cardiovascular Events in an Alopecia Areata Cohort from a US Claims Database

1 citations , June 2023 in “Dermatology and therapy”

This study found that patients with alopecia areata had a higher incidence rate of herpes simplex infection compared to matched individuals without the condition.

research Comparing the Burden of Illness in Patients with Alopecia Areata vs Atopic Dermatitis in the US Population from a Payer Perspective

10 citations , March 2023 in “Journal of Managed Care & Specialty Pharmacy”

This study found that patients with alopecia areata had similar total health care costs as those with atopic dermatitis, despite having fewer comorbidities and prescription medications overall.

research Anxiety, Depression, and Quality of Life in Children and Adults With Alopecia Areata: A Systematic Review and Meta-Analysis

4 citations , November 2022 in “Frontiers in Medicine”

This study found that people with alopecia areata have a higher likelihood of experiencing anxiety and depression, and a moderate negative impact on their quality of life compared to healthy individuals.

A Potential Predictive Role of the Scalp Microbiome Profiling in Patients with Alopecia Areata: Staphylococcus Caprae, Corynebacterium, and Cutibacterium Species

research A Potential Predictive Role of the Scalp Microbiome Profiling in Patients with Alopecia Areata: Staphylococcus Caprae, Corynebacterium, and Cutibacterium Species

3 citations , April 2022 in “Microorganisms”

This study found that the scalp microbiome was more diverse in alopecia areata patients than in healthy controls, and distinctive microbial profiles may be linked to disease severity and prognosis.

research Adult Skin Acute Stress Responses to Short-Term Environmental and Internal Aggression from Exposome Factors

37 citations , June 2021 in “Journal of the European Academy of Dermatology and Venereology”

This review discusses how acute exposures to environmental and internal stressors can quickly alter skin functions, leading to various dermatological symptoms, and calls for more research on these short-term effects.

research Predictive Metagenomic Profiling, Urine Metabolomics, And Human Marker Gene Expression As An Integrated Approach To Study Alopecia Areata

22 citations , April 2020 in “Frontiers in Cellular and Infection Microbiology”

This study found significant differences in scalp microbiome composition and volatile organic metabolites between individuals with alopecia areata and healthy controls, suggesting potential microbiome-related therapeutic interventions for hair growth disorders.

research Scalp Bacterial Shift in Alopecia Areata

48 citations , April 2019 in “PloS one”

This study observed a microbial shift on the scalp of Alopecia areata patients, characterized by an increase in Propionibacterium acnes and a decrease in Staphylococcus epidermidis, compared to healthy controls.