Association Between Scalp Microbiota Imbalance, Disease Severity, and Systemic Inflammatory Markers in Alopecia Areata

October 2024 in “ Dermatology and Therapy ”

Pedro Jesús Gómez‐Arias, Jesús Gay-Mimbrera, Irene Rivera‐Ruiz, Macarena Aguilar-Luque, M. Juan-Cencerrado, Carmen Mochón‐Jiménez, Francisco Gómez‐García, Silvia Sánchez-González, Adriana Ortega‐Hernández, Dulcenombre Gómez‐Garré, Esmeralda Parra-Peralbo, Beatriz Isla-Tejera, Juan Ruano

scalp microbiota alopecia areata inflammation systemic inflammatory markers

TLDR Scalp microbiota changes may be linked to inflammation in Alopecia Areata.

The study explores the potential link between scalp microbiota imbalance and inflammation in Alopecia Areata (AA). While the findings indicate that changes in scalp microbiota may be associated with AA-related inflammation, it remains uncertain if these shifts are a cause or a result of hair loss. The study emphasizes the need for further research to understand the causal relationship and underlying mechanisms.

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research Treatments for Alopecia Areata: A Network Meta-Analysis

October 2023 in “The Cochrane library”

The medicine baricitinib was found to notably improve hair regrowth in alopecia areata, but more research is needed on its side effects and other treatments.

research Clinical and Genetic Aspects of Alopecia Areata: A Cutting Edge Review

1 citations , June 2023 in “Genes”

Hair loss from Alopecia Areata is caused by both genes and environment, with several treatments available but challenges in cost and relapse remain.

Incidence Rates of Infections, Malignancies, Thromboembolism, and Cardiovascular Events in an Alopecia Areata Cohort from a US Claims Database

research Incidence Rates of Infections, Malignancies, Thromboembolism, and Cardiovascular Events in an Alopecia Areata Cohort from a US Claims Database

1 citations , June 2023 in “Dermatology and therapy”

People with Alopecia Areata have more herpes simplex infections but similar rates of cancer, blood clots, and heart disease compared to those without it.

research Comparing the Burden of Illness in Patients with Alopecia Areata vs Atopic Dermatitis in the US Population from a Payer Perspective

10 citations , March 2023 in “Journal of Managed Care & Specialty Pharmacy”

Alopecia areata and atopic dermatitis have similar healthcare costs, but alopecia areata leads to more outpatient and long-term disability expenses.

research Anxiety, Depression, and Quality of Life in Children and Adults With Alopecia Areata: A Systematic Review and Meta-Analysis

4 citations , November 2022 in “Frontiers in Medicine”

People with alopecia areata are more likely to have anxiety and depression and a lower quality of life.

A Potential Predictive Role of the Scalp Microbiome Profiling in Patients with Alopecia Areata: Staphylococcus Caprae, Corynebacterium, and Cutibacterium Species

research A Potential Predictive Role of the Scalp Microbiome Profiling in Patients with Alopecia Areata: Staphylococcus Caprae, Corynebacterium, and Cutibacterium Species

3 citations , April 2022 in “Microorganisms”

People with severe hair loss (Alopecia Areata) have different scalp bacteria than healthy people, which might help predict the condition's progress.

research Adult Skin Acute Stress Responses to Short-Term Environmental and Internal Aggression from Exposome Factors

37 citations , June 2021 in “Journal of the European Academy of Dermatology and Venereology”

Adult skin quickly reacts to short-term environmental and internal stress, leading to various skin issues and the need for protective measures.

research Predictive Metagenomic Profiling, Urine Metabolomics, And Human Marker Gene Expression As An Integrated Approach To Study Alopecia Areata

22 citations , April 2020 in “Frontiers in Cellular and Infection Microbiology”

Alopecia areata may be linked to scalp microbiome differences, suggesting potential treatments with prebiotics, probiotics, and postbiotics.

research Scalp Bacterial Shift in Alopecia Areata

48 citations , April 2019 in “PloS one”

Alopecia areata patients have more Propionibacterium acnes and less Staphylococcus epidermidis on their scalps.