Impact of Scalp Microbiome Imbalance on Alopecia Areata Severity, Inflammatory Markers, and Post-Treatment Changes

    January 2025 in “ Universidad de Córdoba Insitutional Repository (Universidad de Córdoba) ”
    Gómez Arias, Pedro Jesús
    TLDR An imbalanced scalp microbiome may worsen alopecia areata severity and inflammation, but treatment can partially restore balance.
    Este estudio investigó la relación entre el microbioma del cuero cabelludo y la severidad de la alopecia areata (AA) en 35 participantes, divididos en grupos de pacientes con AA sin tratamiento, post-tratamiento, y controles sanos. Se encontró que los pacientes con AA presentaban una disbiosis significativa, con una reducción de la diversidad microbiana y cambios en la composición, especialmente en casos graves que mostraron una sobreabundancia de bacterias gramnegativas asociadas con estados proinflamatorios. Los casos leves tenían mayores proporciones de taxones antiinflamatorios. El tratamiento con inhibidores de la Janus Quinasa (JAK) resultó en una restauración parcial de la diversidad microbiana y una reducción de los marcadores inflamatorios en sangre. Los resultados sugieren que la microbiota del cuero cabelludo puede influir en la inflamación relacionada con la AA, aunque se necesita más investigación para entender la relación causal.
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