Exploring the Scalp Microbiome Landscape: A Cross-Sectional Study of Female Pattern Hair Loss in Indian Women

This study investigates the role of the scalp microbiome in female pattern hair loss (FPHL) by comparing 60 women with FPHL to 60 healthy controls. Using 16S rRNA gene sequencing, researchers found significant differences in the microbiome composition between the groups. Women with FPHL had an increased presence of Propionibacterium spp. and a decreased presence of Staphylococcus spp., indicating microbial dysbiosis that worsened with hair loss severity. Additionally, microbial diversity was lower in those with FPHL, correlating with the severity of hair loss. These findings suggest that alterations in the scalp microbiome are associated with FPHL, and adjusting microbial balance could be a potential therapeutic strategy. The study highlights the importance of the scalp microbiome in FPHL's etiology and suggests new intervention possibilities.