Effective Scald Wound Functional Recovery Patch Achieved by Molecularly Intertwined Electrical and Chemical Message in Self-Adhesive Assemblies
August 2023
in “
ACS applied materials & interfaces
”
scald skin wounds bioactive wound healing patch piezoelectric poly(vinylidene fluoride-co-hexafluoropropylene) PVDF poly(N,N-dimethylacrylamide) PDMAA hydrogel collagen deposition hair follicles regeneration blood vessels regeneration glands regeneration scald wounds wound healing patch collagen hair follicles blood vessels glands
TLDR The patch helps heal minor scald wounds by providing electrical and chemical signals to boost recovery.
This study presents the development of a bioactive wound healing patch designed to aid in the functional recovery of scald skin wounds by providing simultaneous chemical and electrical signals at the molecular level. The patch, which should be used with daily 10-minute massages, is composed of a piezoelectric poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF) film and a self-adhesive poly(N,N-dimethylacrylamide) (PDMAA) hydrogel layer. It adheres reversibly to skin wounds and delivers electrical and chemical stimuli in response to mechanical pressure. Animal experiments demonstrated that the patch effectively promotes the recovery of grade I and shallow grade II scald wounds, enhancing collagen deposition and the regeneration of hair follicles, blood vessels, and glands. This approach suggests a novel concept for the design of tissue engineering and medical treatment materials by molecularly integrating electrical and chemical activity.
