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RhoA promotes epidermal stem cell proliferation via PKN1-cyclin D1 signaling

February 2017 in “ PLoS ONE ”

Fan Wang, Rixing Zhan, Liang Chen, Xia Dai, Wenping Wang, Rui Guo, Xiaoge Li, Zhe Li, Liang Wang, Shupeng Huang, Jie Shen, Shirong Li, Chuan Cao

RhoA epidermal stem cell ESC PKN1 cyclin D1 signaling pathway

TLDR RhoA helps skin stem cells grow, aiding wound healing.

The study demonstrated that RhoA influenced epidermal stem cell (ESC) proliferation through the activation of the PKN1-cyclin D1 signaling pathway in vitro. This finding suggested that RhoA could have been a potential therapeutic target for enhancing wound healing.

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