A Narrative Review of SARS-CoV-2 Variants and Long COVID

    February 2026 in “ Journal of Thoracic Disease ”
    Xinhua Chai, Haoxiang Qi, Xinze Liu, Feng Zhou, Yuli Jiang, Mengdi Wu, Silu Lian, Lumeng Wang, Yongxia Bao
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    Studysummary The authors highlight the need for further research into the link between SARS-CoV-2 variants and long COVID, emphasizing the importance of developing personalized therapies to tackle the significant medical and economic burdens posed by long COVID.
    Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
    This narrative review examines the relationship between SARS-CoV-2 variants and long COVID, a multisystem disease with symptoms like fatigue and neurological issues, affecting an estimated 10% of COVID-19 patients globally. It highlights that variants such as Alpha and Omicron have different impacts on symptom severity, with Omicron linked to fewer long COVID symptoms. Risk factors include age, female gender, and severe initial illness. Current management is symptom-based, with some efficacy from antiviral and anti-inflammatory treatments, while vaccination reduces risk. The review stresses the need for targeted research and individualized treatment strategies to address the medical and economic impacts of long COVID.
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