Review of Fluconazole Properties and Analytical Methods for Its Determination

    July 2011 in “ Critical reviews in analytical chemistry ”
    Josilene Chaves Ruela Corrêa, Hérida Regina Nunes Salgado
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    TLDR The document concludes that validated methods are needed to ensure the quality of fluconazole drugs and that new antifungal medications are necessary due to safety and resistance concerns.
    The document reviewed the properties and analytical methods for determining fluconazole, an antifungal medication used to treat various Candida infections and cryptococcal meningitis. It highlighted fluconazole's effectiveness, pharmacokinetics, and potential adverse effects, including alopecia with prolonged high-dose treatment. The review detailed analytical methods such as titration, spectrophotometry, thin-layer chromatography, gas chromatography, and high-performance liquid chromatography (HPLC), with a particular emphasis on the importance of HPLC. It also discussed the drug's polymorphism and the need for validated analytical methods for quality control of fluconazole-containing pharmaceuticals. The document underscored the necessity for new antifungal drugs due to concerns about drug safety, efficiency, and microbial resistance.
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