A Review of Androgen-Progestin Regimens for Male Contraception

The review concluded that androgen-progestin regimens for male contraception were effective in suppressing spermatogenesis, with injectable and implantable formulations being more successful than noninjectable ones. Studies involving 802 male volunteers from 1960 to 2002 showed that combining progestins with androgens was necessary to avoid androgen deficiency and achieve azoospermia. The review highlighted the need for further large-scale trials to confirm the safety and efficacy of these regimens, with a focus on developing long-acting and noninjectable options. Despite promising results and minimal short-term side effects, long-term safety required further evaluation.