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GlossaryMedroxyprogesterone Acetate

synthetic hormone used in contraceptives and hormone therapy

Medroxyprogesterone Acetate (MPA) is a synthetic form of the hormone progesterone, commonly used in hormonal contraceptives like Depo-Provera and in hormone replacement therapy. It works by preventing ovulation, thickening cervical mucus to block sperm, and altering the uterine lining to prevent pregnancy. Additionally, MPA is used to treat conditions like endometriosis and abnormal uterine bleeding.

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Effects of Depot Medroxyprogesterone Acetate, the Copper IUD, and the Levonorgestrel Implant on Testosterone, Sex Hormone Binding Globulin, and Free Testosterone Levels: Ancillary Study of the ECHO Randomized Clinical Trial

research Effects of Depot Medroxyprogesterone Acetate, the Copper IUD, and the Levonorgestrel Implant on Testosterone, Sex Hormone Binding Globulin, and Free Testosterone Levels: Ancillary Study of the ECHO Randomized Clinical Trial

March 2024 in “BMC women's health”

The levonorgestrel implant increases free testosterone and lowers SHBG more than DMPA-IM and the copper IUD.

research Management of Clinical Side Effects of Depot Medroxyprogesterone Acetate

7 citations , August 2000 in “Journal of Pediatric and Adolescent Gynecology”

To improve use of the contraceptive DMPA among adolescents, effectively manage side effects like menstrual changes and weight gain through counseling and guidance.

research The Pediatrician and the Sexually Active Adolescent

3 citations , December 1997 in “Pediatric Clinics of North America”

Pediatricians should advise sexually active teens on safe sex and STD prevention, and discuss contraceptive options and their side effects.

research Pharmacovigilance Study of Side Effects Associated with Levonorgestrel-Ethinyl Estradiol and Depot Medroxyprogesterone Acetate

January 2024

COCs often cause nausea, vomiting, and hair loss, while Depo-Provera is linked to weight gain.

research Sex Hormones and Related Compounds, Including Hormonal Contraceptives

January 2014 in “Side effects of drugs annual”

Exposure to certain sex hormones can increase health risks, while some hormone therapies may offer benefits for specific conditions.

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community For those that have used anti androgens what is your experience?

in Research/Science 18 upvotes 1 year ago

People discussed their experiences with anti-androgens for hair loss, mentioning side effects like chest pains with RU58841 and skepticism due to lack of safety data, while considering Fluridil as a potential addition to treatment. Some users expressed reluctance to use these chemicals.

community Are we underestimating systemic absorption with homemade/generic Topical Fin? (HPCH vs. PG/Ethanol formulations)

in Research/Science 4 upvotes 4 weeks ago

Topical finasteride may have higher systemic absorption and lower efficacy when using a Propylene Glycol/Ethanol formulation compared to the hydroxypropyl chitosan (HPCH) formulation. The safety profile of topical finasteride relies heavily on the HPCH formulation, and using standard solutions might lead to different pharmacokinetics.

community Cell senescence-targeted treatment for hair loss, has anyone tried any products/enzymes etc. that use this theory

in Research/Science 5 upvotes 10 months ago

DHT causes hair loss by driving cells into senescence, and a polyphenol in black chokeberry may reverse this. A product using this theory is being considered for use alongside finasteride, minoxidil, and microneedling.

community DHT blocking ingredients

in Treatment 6 upvotes 4 years ago

The conversation discusses DHT blocking treatments for hair loss, specifically mentioning Minoxidil, Finasteride, and organic flaxseed oil containing omega-3 fatty acids. It highlights skepticism about alternative treatments and emphasizes the proven effectiveness of Finasteride and Dutasteride.

community 21M Experiencing Increased Shedding After 2.5 Months on Dutasteride; Switch to Finasteride?

in Treatments 207 upvotes 1 week ago

A 21-year-old experienced severe hair loss after stress and tried PRP, mesotherapy, and a topical finasteride + minoxidil solution, which was costly and inconvenient. They switched to dutasteride, experienced heavy shedding, and are considering switching to finasteride, with advice to consult a qualified doctor for further guidance.

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