Response to Minimum Requirements for Reporting Clinical Trials Evaluating the Therapeutic Potential of Platelet-Rich Plasma

August 2020 in “ Journal of The American Academy of Dermatology ”

Lu Yin, Katerina Svigos, Kumar Sukhdeo, Anthony D. Ho, Kristen Lo Sicco, Jerry Shapiro

platelet-rich plasma PRP androgenetic alopecia hair growth split-scalp design placebo randomized controlled trials

TLDR The authors agree that standardizing how PRP methods are reported could help compare results, but note that the link between PRP's contents and hair growth is unclear, and recommend avoiding split-scalp designs in future trials.

The authors, Lu Yin et al., responded to Sharun & Pawde's letter regarding their paper on platelet-rich plasma (PRP) as a treatment for androgenetic alopecia. They acknowledged the variability in PRP preparations and agreed that standardized reporting of PRP methods would benefit the comparison of results across studies. However, they noted that the relationship between PRP components and hair growth outcomes is not fully understood, and current guidelines do not account for all factors that may influence hair growth. They recommended that future PRP trials for androgenetic alopecia avoid a split-scalp design due to potential diffusion of PRP, suggesting instead that patients be assigned to either a placebo or PRP group. The authors welcomed the standardization of PRP preparation reporting to improve the analysis of studies, including randomized controlled trials.

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research Minimum Requirements for Reporting Clinical Trials Evaluating the Therapeutic Potential of Platelet-Rich Plasma

7 citations, August 2020 in “Journal of The American Academy of Dermatology”

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research Heterogeneity in Amount of Growth Factors Secreted by Platelets in Platelet-Rich Plasma Samples from Alopecia Patients

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33 citations, July 2020 in “Journal of The American Academy of Dermatology”

PRP treatment improves hair density and thickness for alopecia, but needs more research.

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research Growth Factor Concentrations in Platelet-Rich Plasma for Androgenetic Alopecia: An Intra-Subject, Randomized, Blinded, Placebo-Controlled, Pilot Study

13 citations, January 2020 in “Experimental Dermatology”

PRP growth factor concentrations vary, no significant hair growth difference found.

research A Randomized Evaluator Blinded Study of Effect of Microneedling in Androgenetic Alopecia: A Pilot Study

136 citations, January 2013 in “International Journal of Trichology”

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