Developmental and Evolutionary Comparative Analysis of a Regulatory Landscape in Mammals and Birds

    August 2021 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Aurélie Hintermann, Isabel Guerreiro, Christopher Chase Bolt … Leonardo Beccari

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study observed that distinct subsets of Hoxd genes in murine vibrissae and chicken feather primordia are regulated by different lineage-specific enhancers, indicating evolutionary changes in chromatin topology contribute to transcriptional robustness.
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    Research cited in this study 6

    1. Mammalian-Specific Ectodermal Enhancers Control the Expression of Hoxc Genes in Developing Nails and Hair Follicles Proceedings of the National Academy of Sciences · 2020
    2. Hoxc-Dependent Mesenchymal Niche Heterogeneity Drives Regional Hair Follicle Regeneration Cell Stem Cell · 2018
    3. Getting to the Root of Scales, Feathers, and Hair: As Deep as Odontodes? Experimental Dermatology · 2017
    4. Early Inductive Events in Ectodermal Appendage Morphogenesis Seminars in cell & developmental biology · 2014
    5. Genetic Basis of Skin Appendage Development Seminars in cell & developmental biology · 2007
    6. Hoxc13 Mutant Mice Lack External Hair Genes & Development · 1998