Refractory Pruritic Fox-Fordyce Disease Successfully Treated With Botulinum Toxin Type A

August 2022 in “ International journal of women’s dermatology ”

Meshal M Alhameedy, Muhammad Tariq

Fox-Fordyce disease pruritus apocrine-rich areas botulinum toxin type A intradermal injections Visual Analogue Scale papules FFD itching Botox VAS

TLDR Botox injections may be a safe and effective way to treat severe, itchy skin disease when other treatments fail.

Fox-Fordyce disease (FFD) is a chronic, pruritic condition affecting apocrine-rich areas, predominantly in young adult women, with no satisfactory treatment options. This case study reports a 30-year-old woman with a 7-year history of refractory FFD who experienced significant improvement after a single session of intradermal botulinum toxin type A (BTX-A) injections. The treatment reduced pruritus from 10/10 to 2/10 on the Visual Analogue Scale and decreased the number of papules, with effects lasting up to 6 months. BTX-A appears to be a promising and safe treatment for FFD, although cost and availability are limiting factors.

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