Recurrent Inverse Necrotizing Infundibular Crystalline Folliculitis
April 2024
in “
Journal of Cutaneous Pathology
”
necrotizing infundibular crystalline folliculitis folliculitis epidermal-derived growth factor vascular endothelial-derived growth factor PD-1 inhibitors sebaceous gland dysfunction EGFR signaling follicular epithelium rupture neutrophilic inflammation crystal deposits epidermal growth factor vascular endothelial growth factor programmed death-1 inhibitors epidermal growth factor receptor signaling
TLDR Recurrent NICF is a rare skin condition with unclear causes, involving follicle inflammation and crystal deposits.
Necrotizing infundibular crystalline folliculitis (NICF) is a rare necrotizing folliculitis with only 23 cases reported in the literature. It typically presents as folliculocentric papules in seborrheic areas and can occur spontaneously or be drug-induced, particularly with therapies involving epidermal-derived growth factor, vascular endothelial-derived growth factor, or PD-1 inhibitors. The condition often involves bacterial and/or yeast colonization, and its etiology is unclear, though it may involve an aberrant microbiome, sebaceous gland dysfunction, and disrupted EGFR signaling. Histopathology shows follicular epithelium rupture, neutrophilic inflammation, and crystal deposits. The document discusses a case of spontaneous, recurrent NICF in the inguinal region.
