Reconstitution of full-thickness skin by microcolumn grafting

The study explored an innovative method for skin tissue engineering by using microcolumn grafting to reconstitute full-thickness skin. Researchers harvested and implanted micrometer-scale columns of human skin tissue, which were then used to treat wounds in immunodeficient mice. This approach successfully restored key features of normal human skin, such as epidermal architecture, diverse cell populations, and functional sweat glands, without causing scarring or significant morbidity at the donor site. These findings indicated that microcolumn grafting could potentially be a viable technique for regenerating fully functional skin in human wounds.