Recent Advances in the Treatment of Trichotillomania (Hair-Pulling Disorder)

Trichotillomania (TTM) is a hair-pulling disorder affecting 0.5% to 2.0% of the population, leading to significant psychological issues. While behavioral therapy has been effective, not all patients can adhere to it, highlighting the need for pharmacological treatments. Traditional medications like fluoxetine, clomipramine, olanzapine, and naltrexone have shown mixed results and often have limiting side effects. Recent advances in understanding TTM's pathophysiology have introduced new potential treatments, particularly glutamate-modulating agents such as N-acetylcysteine and dronabinol, which have shown promise in managing the disorder.