Rat Hair Follicle-Constituting Cells Labeled by a Newly Developed Somatic Stem Cell-Recognizing Antibody: A Possible Marker of Hair Follicle Development.

February 2013 in “ PubMed ”

Chisa Ichikawa, Takeshi Izawa, Vetnizah Juniantito, Miyuu Tanaka, Mayuka Hori, Katsuhiro Tanaka, Shigeo Takenaka, Mitsuru Kuwamura, Jyoji Yamate

somatic stem cells hair follicles A3 antibody outer root sheath suprabasal epithelial cells mesenchymal cells

TLDR A3 antibody helps identify key cells in rat hair follicle development.

The study developed an antibody, A3, to identify somatic stem cells in rat tissues and examined its presence in developing rat hair follicles. A3-positive cells were found in the hair germ and peg of fetuses and neonates, and in the outer root sheath of mature follicles. These cells were identified as suprabasal epithelial cells and immature mesenchymal cells with stem cell characteristics, but they did not show proliferative activity. The findings suggested that A3-positive cells in developing hair follicles were quiescent post-progenitor cells with potential for differentiation. A3 was considered a valuable tool for studying the dynamics of hair follicle cells in rats.

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