Rat Hair Follicle-Constituting Cells Labeled by a Newly Developed Somatic Stem Cell-Recognizing Antibody: A Possible Marker of Hair Follicle Development.

February 2013 in “ PubMed ”

Chisa Ichikawa, Takeshi Izawa, Vetnizah Juniantito, Miyuu Tanaka, Mayuka Hori, Katsuhiro Tanaka, Shigeo Takenaka, Mitsuru Kuwamura, Jyoji Yamate

somatic stem cells hair follicles A3 antibody outer root sheath suprabasal epithelial cells mesenchymal cells

TLDR A3 antibody helps identify key cells in rat hair follicle development.

The study developed an antibody, A3, to recognize somatic stem cells in rat tissues and investigated its distribution in developing rat hair follicles. A3-positive cells were identified in the hair germ and peg of fetuses and neonates, and in the outer root sheath of mature hair follicles. These cells were epithelial and mesenchymal in nature, with the potential to differentiate into highly-differentiated cells, but did not show proliferating activity. The findings suggested that A3-positive cells might be quiescent post-progenitor cells, and A3 could serve as a useful marker for studying the development of hair follicle-constituting cells.

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There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

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community What should we lookout for in the near future for hairloss?

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community EU Shouldn't Ban Fin & Dut: PFS is NOT REAL.

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community When you're balding is it an absolute traumatic period of your life or do some people not care as much?

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in General 97 upvotes 2 months ago

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