RANKL Biology: Bone Metabolism, the Immune System, and Beyond

    February 2020 in “ Inflammation and Regeneration ”
    T. Ono, Mikihito Hayashi, F Sasaki, Tomoki Nakashima
    Studysummary This review discusses the diverse roles of the RANKL/RANK/OPG system in bone metabolism, the immune system, and other biological processes, emphasizing its relevance in the field of osteoimmunology, but reports no new results. Our plain-language summary of this paper — not a Tressless recommendation.
    The document reviewed the functions of the RANKL/RANK/OPG system, highlighting its critical role in bone resorption and the immune system, which are foundational to the field of "osteoimmunology." Abnormalities in this system were linked to bone diseases like osteopetrosis. Beyond bone metabolism and immune functions, RANKL was also involved in processes such as mammary gland and hair follicle formation, body temperature regulation, muscle metabolism, and tumor development. The review summarized the then-current understanding of these diverse biological roles of the RANKL/RANK/OPG system.
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