TLDR RANKL is crucial for bone health, immune function, and other body processes.
The document reviewed the functions of the RANKL/RANK/OPG system, highlighting its critical role in bone resorption and the immune system, which are foundational to the field of "osteoimmunology." Abnormalities in this system were linked to bone diseases like osteopetrosis. Beyond bone metabolism and immune functions, RANKL was also involved in processes such as mammary gland and hair follicle formation, body temperature regulation, muscle metabolism, and tumor development. The review summarized the then-current understanding of these diverse biological roles of the RANKL/RANK/OPG system.
60 citations
,
March 2011 in “Proceedings of the National Academy of Sciences of the United States of America” RANK-RANKL signaling is essential for hair growth and skin health.
50 citations
,
January 2016 in “The FEBS journal” RANK is a key target in breast cancer treatment due to its role in tumor growth and bone metastasis.
66 citations
,
May 2021 in “Science Advances” Different scaffold patterns improve wound healing and immune response in mouse skin, with aligned patterns being particularly effective.
42 citations
,
December 2011 in “The journal of immunology/The Journal of immunology” RANKL causes lymph nodes to grow by making certain cells multiply.
3 citations
,
September 2021 in “JAAD case reports” Denosumab, a bone loss treatment, may cause hair loss and skin reactions due to immune system effects.
60 citations
,
March 2011 in “Proceedings of the National Academy of Sciences of the United States of America” RANK-RANKL signaling is essential for hair growth and skin health.
