Developing Humanized Animal Models with Transplantable Human iPSC-Derived Cells

January 2024 in “ Frontiers in Bioscience-Landmark ”

Min Ma, Jian-Yun Ge, Yunzhong Nie, Yumei Li, Yun‐Wen Zheng

Studysummary This paper reviews current developments in humanized animal models for disease modeling and drug screening, highlighting advances in gene editing and stem cell technologies as key to creating more human-like models for research purposes.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on imrpress.com →

Discuss this study in the Community →

Research cited in this study

4 / 4 results

research Human iPS Cell-Derived Cell Aggregates Exhibited Dermal Papilla Cell Properties in In Vitro Three-Dimensional Assemblage Mimicking Hair Follicle Structures

10 citations , August 2021 in “Frontiers in cell and developmental biology”

This study suggests the possibility of regenerating hair follicle structures in vitro using hiPSC-derived cell composites, which might reduce reliance on human tissue-derived cells for hair bioengineering.

Evidence from a Humanized Mouse Model of Androgenetic Alopecia That Platelet-Rich Plasma Stimulates Hair Regrowth, Hair Shaft Diameter, and Vellus-to-Terminal Hair Reconversion In Vivo

research Evidence from a Humanized Mouse Model of Androgenetic Alopecia That Platelet-Rich Plasma Stimulates Hair Regrowth, Hair Shaft Diameter, and Vellus-to-Terminal Hair Reconversion In Vivo

March 2021 in “British Journal of Dermatology”

This study using a humanized mouse model of androgenetic alopecia suggests that platelet-rich plasma may promote hair regrowth and improve hair characteristics in vivo.

research Alopecia Areata: Animal Models Illuminate Autoimmune Pathogenesis and Novel Immunotherapeutic Strategies

82 citations , March 2016 in “Autoimmunity reviews”

This review explores animal models of alopecia areata, particularly focusing on the insights they've provided into the disease's immune mechanisms and potential treatment approaches, without reporting new experimental data.

research The Growth of Human Hair in Nude Mice

1 citations , October 1996 in “Dermatologic clinics”

This study found that higher levels of adiponectin were associated with reduced inflammation and osteolysis, suggesting potential therapeutic benefits for patients with aseptic loosening of joint replacements.