Eculizumab in the Management of Catastrophic Antiphospholipid Syndrome with Multiorgan Involvement: A Case Report

In this clinical case study, a 30-year-old man with systemic lupus erythematosus was diagnosed with both catastrophic antiphospholipid syndrome and acquired haemophilia A, successfully treated with immunosuppressive therapy, plasma exchange, and IVIG, leading to a favourable outcome.

This study reports a case of a patient with neuromyelitis optica spectrum disorders treated with eculizumab who developed fatal sepsis after insulin resistance emerged.

This case report highlights a rare instance of diffuse alveolar hemorrhage in a patient with catastrophic antiphospholipid syndrome, emphasizing the importance of early recognition and multidisciplinary management.

This case report details a rare instance of primary adrenal insufficiency as a manifestation of antiphospholipid syndrome, with the patient successfully managed through glucocorticoids, warfarin, and hydroxychloroquine.

This case report describes how anifrolumab, used beyond trial-eligible populations, led to significant clinical and serological recovery in a 45-year-old woman with organ-threatening systemic lupus erythematosus complicated by infection and resistant to conventional treatments like cyclophosphamide and rituximab.