Designed, Synthesis, In Vitro and Computational Analyses of Anticancer Nicotinamide Derivatives
February 2024
in “
Indian Journal of Chemistry
”
Studysummary In this study, researchers synthesized nine new nicotinamide derivative compounds and found that one, identified as N4, exhibited significant cytotoxic effects on MCF-7 breast cancer cells, while other derivatives demonstrated notable antibacterial, antifungal, and antibiofilm activities.
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In this study, nine new nicotinamide derivative compounds were designed and synthesized, with their characterization performed using in silico methods. The anticancer effects were tested on four different cancer types and compared to healthy fibroblast cells, revealing that compound N4 had a significant cytotoxic effect on MCF-7 human breast cancer cells with an IC50 value of 12.1 μM. Additionally, the compounds exhibited notable antibacterial, antifungal, and antibiofilm activities, particularly N2 and N3. The anticancer properties were further analyzed using in silico techniques, including detailed pharmacophore mapping and ADME analyses.
