Distribution of Quantum Dot Nanoparticles That Penetrate Skin and Distinction of Combined Osmium Tetroxide in Electron Microscopic Analysis

    March 2012 in “ Korean Journal of Microscopy ”
    Ki-Ju Choi, Sang‐Yong Park, Jeong Min Lee, H J Shin, Jae‐Kyung Jung, Don‐Gil Lee, Garfurjon T. Mavonov, Tae–Hoo Yi
    Image of study
    TLDR Quantum dot nanoparticles can penetrate skin and reach sebocytes through hair follicles.
    The study investigated the penetration of quantum dot nanoparticles into the skin, revealing that these particles could penetrate the stratum corneum and reach sebocytes via hair follicles. A significant challenge was distinguishing the nanoparticles from artifacts caused by the combination of free fatty acids and osmium tetroxide during specimen preparation. By employing different sample processing techniques and comparing cross-correlation image patterns, researchers were able to accurately determine the distribution of the nanoparticles, thereby reducing errors in analysis. This method was anticipated to enhance the accuracy of nanoparticle distribution studies in biomedical research.
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