First-In-Human Phase 1 Study of ETC-159, an Oral PORCN Inhibitor in Patients with Advanced Solid Tumors
May 2017
in “
Journal of Clinical Oncology
”
Studysummary This phase I study reported that ETC-159, targeting Wnt signalling, showed tolerable safety profiles at doses that inhibit its pathway, though bone turnover markers increased, warranting early and regular monitoring. No tumor responses were observed, but two patients achieved stable disease for several cycles.
Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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