Nanozyme Catalysis Restores Hair Follicle Integrity by Reversing Peroxisomal Collapse

The study identifies peroxisomal dysfunction as a key factor in hair follicle degeneration and alopecia, highlighting its role in disrupting metabolic and redox homeostasis. Researchers found that peroxisome-associated pathways were downregulated in alopecia patients, leading to hair thinning and follicle miniaturization. To counteract this, they developed catalytic nanozymes that mimic peroxisomal catalase activity, which restored metabolic balance, reduced oxidative damage, and stimulated hair follicle regeneration in murine models. Nanozyme treatment increased PPARα expression, enhancing peroxisomal and mitochondrial function, and showed greater efficacy than minoxidil, suggesting a promising metabolism-focused therapeutic strategy for alopecia.