Comparison of the Combination of PRP and Topical Minoxidil to Topical Minoxidil Alone on Androgenetic Alopecia

    December 2025 in “ JMU Scholoraly Commons (James Madison University) ”
    Leia Hyunyoung Son, Ashley Olivia Owens
    From the encyclopedia
    Platelet-Rich Plasma →

    growth factors taken from your blood and injected into your scalp to stimulate hair

    Minoxidil →

    An essential vasodilator with some anti-androgenic effects

    Studysummary This study found that combining platelet-rich plasma with topical 5% minoxidil increased hair density and patient satisfaction more than minoxidil alone in treating androgenetic alopecia. Our plain-language summary of this paper — not a Tressless recommendation.
    The study systematically reviewed three randomized controlled trials to compare the efficacy of combining platelet-rich plasma (PRP) with topical 5% minoxidil versus using topical minoxidil alone for treating androgenetic alopecia (AGA). Results indicated that the combination therapy led to increased hair density and higher patient satisfaction compared to minoxidil alone. Despite these positive outcomes, PRP is not FDA-approved for AGA and is considered an off-label treatment. The study concludes that further research is necessary to assess the long-term efficacy and potential need for maintenance therapy with this combination treatment.
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