Platelet-Rich Plasma-Derived Exosomes Modulate Follicular Regeneration: A Comparative Mechanistic Analysis with Minoxidil in a Preclinical Model of Androgenetic Alopecia

This study investigates the efficacy of platelet-rich plasma-derived exosomes (PRP-Exo) in treating androgenetic alopecia (AGA) using a murine model. Thirty-two male mice were divided into four groups to receive different treatments, including PRP-Exo, minoxidil, and a combination of both. Results showed that all treatments improved hair regeneration compared to the control, with the combination therapy yielding the most significant improvements in hair follicle density, anagen-to-telogen ratio, and hair shaft thickness. The combination therapy also increased tissue levels of Ki-67 and β-catenin, indicating enhanced cell proliferation and activation of the Wnt signaling pathway. The findings suggest that PRP-Exo, especially when combined with minoxidil, could be a potent next-generation therapy for AGA.