Platelet-Rich Plasma-Derived Exosomes Modulate Follicular Regeneration: A Comparative Mechanistic Analysis with Minoxidil in a Preclinical Model of Androgenetic Alopecia

September 2025 in “ Bioscientia Medicina Journal of Biomedicine and Translational Research ”

Trya Oktaviani, Arie Kusumawardani, Suci Widhiati, Nugrohoaji Dharmawan, Endra Yustin Ellistasari

platelet-rich plasma-derived exosomes minoxidil androgenetic alopecia hair follicle density anagen-to-telogen ratio hair shaft thickness Ki-67 β-catenin Wnt signaling pathway PRP-Exo Rogaine AGA

TLDR Combining PRP-Exo with minoxidil significantly improves hair growth in androgenetic alopecia.

This study investigates the efficacy of platelet-rich plasma-derived exosomes (PRP-Exo) in treating androgenetic alopecia (AGA) using a murine model. Thirty-two male mice were divided into four groups to receive different treatments, including PRP-Exo, minoxidil, and a combination of both. Results showed that all treatments improved hair regeneration compared to the control, with the combination therapy yielding the most significant improvements in hair follicle density, anagen-to-telogen ratio, and hair shaft thickness. The combination therapy also increased tissue levels of Ki-67 and β-catenin, indicating enhanced cell proliferation and activation of the Wnt signaling pathway. The findings suggest that PRP-Exo, especially when combined with minoxidil, could be a potent next-generation therapy for AGA.

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